Further Information
Sialic acid-binding Ig-like lectin 7, Siglec-7, Adhesion inhibitory receptor molecule 1, AIRM-1, CDw328, D-siglec, QA79 membrane protein, p75, CD328, SIGLEC7, AIRM1
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:50~100
SIGLECs are cell surface proteins of the Ig superfamily. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. A large subgroup of SIGLECs share high homology with SIGLEC3 (CD33) and are localized to 19q13.4. The cDNA for the SLG gene encodes 2 variants, SLG-long (SLGL) and SLG-short (SLGS). The 595-amino acid SLGL protein contains a signal peptide and 2 V-set N-terminal Ig-like domains. The 477-amino acid SLGS protein has a weak signal sequence and, like most SIGLEC3-like SIGLECs, has only 1 V-set N-terminal Ig-like domain. Both variants contain 2 C2-set N-terminal Ig-like domains, a transmembrane domain, and a cytoplasmic tail with a putative ITIM and a putative SLAM-like tyrosine-based motif. The conserved arginine residue thought to be essential for sialic acid binding in other SIGLECs is replaced by a glutamine in SLGS and by a cysteine in SLGL. RT-PCR analysis detected high expression of both variants in spleen and small intestine, and SLGS was highly expressed in adrenal gland and SLGL was highly expressed in bone marrow.
- Nicoll, G., et al., Eur. J. Immunol. 33(6):1642-1648 (2003).
- Alphey, M.S., et al., J. Biol. Chem. 278(5):3372-3377 (2003).
- Angata, T., et al., Glycobiology 10(4):431-438 (2000).
- Falco, M., et al., J. Exp. Med. 190(6):793-802 (1999).
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
This SIGLEC7 (D-siglec) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 407-438 amino acids from the C-terminal region of human SIGLEC7 (D-siglec).
27036
Sialic acid-binding Ig-like lectin 7
SIGLEC7
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
51 kDa
Q9Y286
25009269
This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunology,Neuroscience,Signal Transduction
Q9Y286
Optimal dilutions for each application to be determined by the researcher.