ProSci

HAMP Antibody

Product Code:
 
PSI-63-955
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Western Blot at 1:500 dilution + human liver lysate Lysates/proteins at 20 ug per lane.
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Western blot analysis of HAMP Antibody in MDA-MB435 cell line lysates (35ug/lane)
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Western Blot at 1:500 dilution + human liver lysate Lysates/proteins at 20 ug per lane.
Western blot analysis of HAMP Antibody in MDA-MB435 cell line lysates (35ug/lane)

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PSI-63-955-400ul400ul£626.00
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Further Information

Additional Names:
Hepcidin, Liver-expressed antimicrobial peptide 1, LEAP-1, Putative liver tumor regressor, PLTR, Hepcidin-25, Hepc25, Hepcidin-20, Hepc20, HAMP, HEPC, LEAP1
Application Note:
For WB starting dilution is: 1:500
Background:
HAMP is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity.
Background References:
  • Matsumoto, M., et al. Circ. J. 74(2):301-306(2010)
  • del Giudice, E.M., et al. J. Clin. Endocrinol. Metab. 94(12):5102-5107(2009)
  • Kwapisz, J., et al.Zhejiang Univ Sci10(11):791-795(2009)
  • Barton, J.C., et al. Am. J. Hematol. 84(11):710-714(2009)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This HAMP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 17-46 amino acids from the Central region of human HAMP.
NCBI Gene ID #:
57817
NCBI Official Name:
Hepcidin
NCBI Official Symbol:
HAMP
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
9 kDa
Protein Accession #:
P81172
Protein GI Number:
10720397
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Immunology,Obesity,Signal Transduction
Swissprot #:
P81172
User NOte:
Optimal dilutions for each application to be determined by the researcher.