Further Information
Phosphatidylinositol 3,5-trisphosphate 5-phosphatase 1, Inositol polyphosphate-5-phosphatase of 145 kDa, SIP-145, SH2 domain-containing inositol 5'-phosphatase 1, SH2 domain-containing inositol phosphatase 1, SHIP-1, p150Ship, hp51CN, INPP5D, SHIP, SHIP1
For WB starting dilution is: 1:1000
INPP5D is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and it is a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. Overall, the protein functions as a negative regulator of myeliod cell proliferation and survival.
- Gilby,D.C., Leukemia 21 (11), 2390-2393 (2007)
- Gloire,G., Biochem. Soc. Trans. 35 (PT 2), 277-280 (2007)
- Vaillancourt,M., Cell. Signal. 18 (11), 2022-2032 (2006)
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Predicted species reactivity based on immunogen sequence: Mouse, Rat
This INPP5D antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 770-796 amino acids from the Central region of human INPP5D.
3635
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1
INPP5D
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
133 kDa
Q92835
158564077
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Immunology,Signal Transduction
Q92835
Optimal dilutions for each application to be determined by the researcher.