ProSci

ITGB2 Antibody

Product Code:
 
PSI-59-652
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Western blot analysis in 293 cell line lysates (35ug/lane).
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Western blot analysis in 293 cell line lysates (35ug/lane).

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PSI-59-652-400ul400ul£626.00
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Further Information

Additional Names:
Integrin beta-2, Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta, Complement receptor C3 subunit beta, CD18, ITGB2, CD18, MFI7
Application Note:
For WB starting dilution is: 1:1000
Background:
The product of this gene belongs to the integrin beta chain family of proteins. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. This gene encodes the integrin beta chain beta 2. A given chain may combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Defects in this gene are the cause of leukocyte adhesion deficiency type I (LAD1). Two transcript variants encoding the same protein have been identified for this gene.
Background References:
  • Gjelstrup, L.C., et al. J. Immunol. 185(7):4154-4168(2010)
  • Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)
  • Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
  • Chen, X., et al. Proc. Natl. Acad. Sci. U.S.A. 107(33):14727-14732(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This ITGB2 antibody is generated from rabbits immunized with a recombinant protein from the human ITGB2.
NCBI Gene ID #:
3689
NCBI Official Name:
Integrin beta-2
NCBI Official Symbol:
ITGB2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
85 kDa
Protein Accession #:
P05107
Protein GI Number:
124056465
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Immunology,Signal Transduction
Swissprot #:
P05107
User NOte:
Optimal dilutions for each application to be determined by the researcher.