Antibody Isotype:
Rabbit Ig
Antibody Clonality:
Polyclonal
Applications:- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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![Western blot analysis in HepG2 cell line lysates (35ug/lane). Western blot analysis in HepG2 cell line lysates (35ug/lane).](https://www.prosci-inc.com/static-images/57-823_1.jpg)
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![SIGLEC8 Antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. SIGLEC8 Antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.](https://www.prosci-inc.com/static-images/57-823_2.jpg)
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This product comes from:
United States.
Typical lead time:
14-21 working days.
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- Further Information
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Further Information
Sialic acid-binding Ig-like lectin 8, Siglec-8, Sialoadhesin family member 2, SAF-2, SIGLEC8, SAF2
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
Sialic acid-binding immunoglobulin (Ig)-like lectins, or
SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1
transmembrane proteins each having a unique expression pattern,
mostly in hemopoietic cells. SIGLEC8 is a member of the CD33-like
subgroup of SIGLECs, which are localized to 19q13.3-q13.4 and have
2 conserved cytoplasmic tyrosine-based motifs: an immunoreceptor
tyrosine-based inhibitory motif, or ITIM (see MIM 604964), and a
motif homologous to one identified in signaling lymphocyte
activation molecule (SLAM; MIM 603492) that mediates an association
with SLAM-associated protein (SAP; MIM 300490) (summarized by
Foussias et al., 2000 [PubMed 11095983]).
- Gao, P.S., et al. Eur. J. Hum. Genet. 18(6):713-719(2010)
- Davila, S., et al. Genes Immun. 11(3):232-238(2010)
- Hudson, S.A., et al. J. Pharmacol. Exp. Ther. 330(2):608-612(2009)
- Bochner, B.S. Clin. Exp. Allergy 39(3):317-324(2009)
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
This SIGLEC8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 94-122 amino acids from the N-terminal region of human SIGLEC8.
27181
Sialic acid-binding Ig-like lectin 8
SIGLEC8
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
54 kDa
Q9NYZ4
25009268
This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunology,Signal Transduction
Q9NYZ4
Optimal dilutions for each application to be determined by the researcher.