Further Information
Potassium voltage-gated channel subfamily A member 4, HPCN2, Voltage-gated K(+) channel HuKII, Voltage-gated potassium channel HBK4, Voltage-gated potassium channel HK1, Voltage-gated potassium channel subunit Kv14, KCNA4, KCNA4L
For WB starting dilution is: 1:1000
Potassium channels represent the most complex class of
voltage-gated ion channels from both functional and structural
standpoints. Their diverse functions include regulating
neurotransmitter release, heart rate, insulin secretion, neuronal
excitability, epithelial electrolyte transport, smooth muscle
contraction, and cell volume. Four sequence-related potassium
channel genes - shaker, shaw, shab, and shal - have been identified
in Drosophila, and each has been shown to have human homolog(s).
This gene encodes a member of the potassium channel, voltage-gated,
shaker-related subfamily. This member contains six
membrane-spanning domains with a shaker-type repeat in the fourth
segment. It belongs to the A-type potassium current class, the
members of which may be important in the regulation of the fast
repolarizing phase of action potentials in heart and thus may
influnce the duration of cardiac action potential. The coding
region of this gene is intronless, and the gene is clustered with
genes KCNA3 and KCNA10 on chromosome 1.
- Schwetz, T.A., et al. Biochim. Biophys. Acta 1798(3):367-375(2010)
- Angelova, P.R., et al. Eur. J. Neurosci. 29(10):1943-1950(2009)
- Mckeown, L., et al. J. Biol. Chem. 283(44):30421-30432(2008)
- Lee, J.H., et al. Mol. Pharmacol. 73(3):619-626(2008)
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Rat
This KCNA4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 591-619 amino acids from the C-terminal region of human KCNA4.
3739
Potassium voltage-gated channel subfamily A member 4
KCNA4
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
73 kDa
P22459
313104127
This antibody is purified through a protein A column, followed by peptide affinity purification.
Neuroscience
P22459
Optimal dilutions for each application to be determined by the researcher.