Antibody Isotype:
Rabbit Ig
Antibody Clonality:
Polyclonal
Applications:- Fluorescence-activated cell sorting (FACS)
- Immunofluorescence (IF)
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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This product comes from:
United States.
Typical lead time:
14-21 working days.
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- Further Information
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Further Information
Beta-arrestin-1, Arrestin beta-1, ARRB1, ARR1
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
For IF starting dilution is: 1:10~50
For FACS starting dilution is: 1:10~50
Members of arrestin/beta-arrestin protein family are
thought to participate in agonist-mediated desensitization of
G-protein-coupled receptors and cause specific dampening of
cellular responses to stimuli such as hormones, neurotransmitters,
or sensory signals. Arrestin beta 1 is a cytosolic protein and
acts as a cofactor in the beta-adrenergic receptor kinase (BARK)
mediated desensitization of beta-adrenergic receptors. Besides the
central nervous system, it is expressed at high levels in
peripheral blood leukocytes, and thus the BARK/beta-arrestin system
is believed to play a major role in regulating receptor-mediated
immune functions. Alternatively spliced transcripts encoding
different isoforms of arrestin beta 1 have been described, however,
their exact functions are not known.
- Shukla, A.K., et al. J. Biol. Chem. 285(39):30115-30125(2010)
- Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
- Lee, D.K., et al. Biochem. Biophys. Res. Commun. 395(2):185-189(2010)
- Kim, J.I., et al. Mol. Cancer Res. 8(4):569-577(2010)
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Rabbit, Rat
This ARRB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 336-363 amino acids from the C-terminal region of human ARRB1.
408
Beta-arrestin-1
ARRB1
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
47 kDa
P49407
20141238
This antibody is purified through a protein A column, followed by peptide affinity purification.
Neuroscience,Signal Transduction
P49407
Optimal dilutions for each application to be determined by the researcher.