Further Information
Na(+)/H(+) exchange regulatory cofactor NHE-RF3, NHERF-3, CFTR-associated protein of 70 kDa, Na(+)/H(+) exchanger regulatory factor 3, Na/Pi cotransporter C-terminal-associated protein 1, NaPi-Cap1, PDZ domain-containing protein 1, Sodium-hydrogen exchanger regulatory factor 3, PDZK1, CAP70, NHERF3, PDZD1
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. May function to connect SCARB1 with the cellular machineries for intracellular cholesterol transport and/or metabolism. May be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function (By similarity).
- Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
- LaLonde, D.P., et al. Mol. Biol. Cell 21(9):1519-1529(2010)
- Polasek, O., et al. Croat. Med. J. 51(1):32-39(2010)
- Gunjaca, G., et al. Croat. Med. J. 51(1):23-31(2010)
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
This PDZK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 196-224 amino acids from the Central region of human PDZK1.
5174
Na(+)/H(+) exchange regulatory cofactor NHE-RF3
PDZK1
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
57 kDa
Q5T2W1
73621372
This antibody is purified through a protein A column, followed by peptide affinity purification.
Obesity,Signal Transduction
Q5T2W1
Optimal dilutions for each application to be determined by the researcher.