Further Information
V-type proton ATPase subunit B, kidney isoform, V-ATPase subunit B 1, Endomembrane proton pump 58 kDa subunit, Vacuolar proton pump subunit B 1, ATP6V1B1, ATP6B1, VATB, VPP3
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
This gene encodes a component of vacuolar ATPase
(V-ATPase), a multisubunit enzyme that mediates acidification of
eukaryotic intracellular organelles. V-ATPase dependent organelle
acidification is necessary for such intracellular processes as
protein sorting, zymogen activation, receptor-mediated endocytosis,
and synaptic vesicle proton gradient generation. V-ATPase is
composed of a cytosolic V1 domain and a transmembrane V0 domain.
The V1 domain consists of three A and three B subunits, two G
subunits plus the C, D, E, F, and H subunits. The V1 domain
contains the ATP catalytic site. The V0 domain consists of five
different subunits: a, c, c', c'', and d. Additional isoforms of
many of the V1 and V0 subunit proteins are encoded by multiple
genes or alternatively spliced transcript variants. This encoded
protein is one of two V1 domain B subunit isoforms and is found in
the kidney. Mutations in this gene cause distal renal tubular
acidosis associated with sensorineural deafness. [provided by
RefSeq].
- Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
- Sharifian, M., et al. IranKidney Dis 4(3):202-206(2010)
- Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
- Andreucci, E., et al. Pediatr. Nephrol. 24(11):2147-2153(2009)
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
This ATP6V1B1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 472-501 amino acids from the C-terminal region of human ATP6V1B1.
525
V-type proton ATPase subunit B, kidney isoform
ATP6V1B1
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
57 kDa
P15313
215274116
This antibody is purified through a protein A column, followed by peptide affinity purification.
Obesity,Signal Transduction
P15313
Optimal dilutions for each application to be determined by the researcher.