Antibody Isotype:
Rabbit Ig
Antibody Clonality:
Polyclonal
Applications:- Fluorescence-activated cell sorting (FACS)
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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This product comes from:
United States.
Typical lead time:
14-21 working days.
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- Further Information
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Further Information
Protoheme IX farnesyltransferase, mitochondrial, 251-, Heme O synthase, COX10
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:50~100
For FACS starting dilution is: 1:10~50
Cytochrome c oxidase (COX), the terminal component of the
mitochondrial respiratory chain, catalyzes the electron transfer
from reduced cytochrome c to oxygen. This component is a
heteromeric complex consisting of 3 catalytic subunits encoded by
mitochondrial genes and multiple structural subunits encoded by
nuclear genes. The mitochondrially-encoded subunits function in
electron transfer, and the nuclear-encoded subunits may function in
the regulation and assembly of the complex. This nuclear gene
encodes heme A:farnesyltransferase, which is not a structural
subunit but required for the expression of functional COX and
functions in the maturation of the heme A prosthetic group of COX.
This protein is predicted to contain 7-9 transmembrane domains
localized in the mitochondrial inner membrane. A gene mutation,
which results in the substitution of a lysine for an asparagine
(N204K), is identified to be responsible for cytochrome c oxidase
deficiency. In addition, this gene is disrupted in patients with
CMT1A (Charcot-Marie-Tooth type 1A) duplication and with HNPP
(hereditary neuropathy with liability to pressure palsies)
deletion.
- Chen, Z., et al. Oncogene 29(30):4362-4368(2010)
- Vitali, M., et al.Neural Transm 116(12):1635-1641(2009)
- Dassa, E.P., et al. EMBO Mol Med 1(1):30-36(2009)
- Veluthakal, R., et al. Diabetes 56(1):204-210(2007)
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
This COX10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 383-410 amino acids from the C-terminal region of human COX10.
1352
Protoheme IX farnesyltransferase, mitochondrial
COX10
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
49 kDa
Q12887
292495084
This antibody is purified through a protein A column, followed by peptide affinity purification.
Obesity,Signal Transduction
Q12887
Optimal dilutions for each application to be determined by the researcher.