Antibody Isotype:
Rabbit Ig
Antibody Clonality:
Polyclonal
Application:
Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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This product comes from:
United States.
Typical lead time:
14-21 working days.
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Further Information
Dual specificity protein phosphatase 10, Mitogen-activated protein kinase phosphatase 5, MAP kinase phosphatase 5, MKP-5, DUSP10, MKP5
For WB starting dilution is: 1:1000
Dual specificity protein phosphatases inactivate their
target kinases by dephosphorylating both the
phosphoserine/threonine and phosphotyrosine residues. They
negatively regulate members of the MAPK superfamily (MAPK/ERK,
SAPK/JNK, p38), which is associated with cellular proliferation and
differentiation. Different members of this family of dual
specificity phosphatases show distinct substrate specificities for
MAPKs, different tissue distribution and subcellular localization,
and different modes of inducibility of their expression by
extracellular stimuli. This gene product binds to and inactivates
p38 and SAPK/JNK, but not MAPK/ERK. Its subcellular localization is
unique; it is evenly distributed in both the cytoplasm and the
nucleus. This gene is widely expressed in various tissues and
organs, and its expression is elevated by stress stimuli. Three
transcript variants encoding two different isoforms have been found
for this gene.
- Bailey, S.D., et al. Diabetes Care (2010) In press :
- Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
- Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
- Tephly, L.A., et al. Am. J. Respir. Cell Mol. Biol. 39(1):113-123(2008)
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Predicted species reactivity based on immunogen sequence: Bovine, Mouse
This DUSP10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 204-232 amino acids from the Central region of human DUSP10.
11221
Dual specificity protein phosphatase 10
DUSP10
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
53 kDa
Q9Y6W6
20138090
This antibody is purified through a protein A column, followed by peptide affinity purification.
Signal Transduction
Q9Y6W6
Optimal dilutions for each application to be determined by the researcher.