Antibody Isotype:
Rabbit Ig
Antibody Clonality:
Polyclonal
Application:
Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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This product comes from:
United States.
Typical lead time:
14-21 working days.
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Further Information
Troponin T, fast skeletal muscle, TnTf, Beta-TnTF, Fast skeletal muscle troponin T, fTnT, TNNT3
For WB starting dilution is: 1:1000
The binding of Ca(2+) to the trimeric troponin complex
initiates the process of muscle contraction. Increased Ca(2+)
concentrations produce a conformational change in the troponin
complex that is transmitted to tropomyosin dimers situated along
actin filaments. The altered conformation permits increased
interaction between a myosin head and an actin filament which,
ultimately, produces a muscle contraction. The troponin complex has
protein subunits C, I, and T. Subunit C binds Ca(2+) and subunit I
binds to actin and inhibits actin-myosin interaction. Subunit T
binds the troponin complex to the tropomyosin complex and is also
required for Ca(2+)-mediated activation of actomyosin ATPase
activity. There are 3 different troponin T genes that encode
tissue-specific isoforms of subunit T for fast skeletal-, slow
skeletal-, and cardiac-muscle. This gene encodes fast skeletal
troponin T protein; also known as troponin T type 3. Alternative
splicing results in multiple transcript variants encoding
additional distinct troponin T type 3 isoforms. A developmentally
regulated switch between fetal/neonatal and adult troponin T type 3
isoforms occurs. Additional splice variants have been described but
their biological validity has not been established. Mutations in
this gene may cause distal arthrogryposis multiplex congenita type
2B (DA2B).
- Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
- Turnbull, C., et al. Nat. Genet. 42(6):504-507(2010)
- Vihola, A., et al. Acta Neuropathol. 119(4):465-479(2010)
- Jugessur, A., et al. PLoS ONE(7), E11493 (2010) :
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Predicted species reactivity based on immunogen sequence: Mouse, Rat
This TNNT3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 217-245 amino acids from the C-terminal region of human TNNT3.
7140
Troponin T, fast skeletal muscle
TNNT3
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
32 kDa
P45378
33518637
This antibody is purified through a protein A column, followed by peptide affinity purification.
Signal Transduction
P45378
Optimal dilutions for each application to be determined by the researcher.