ProSci

ATP2B4 Antibody

Product Code:
 
PSI-57-793
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Western blot analysis in HepG2 cell line lysates (35ug/lane).
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Western blot analysis in HepG2 cell line lysates (35ug/lane).

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PSI-57-793-400ul400ul£626.00
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Further Information

Additional Names:
Plasma membrane calcium-transporting ATPase 4, PMCA4, Matrix-remodeling-associated protein 1, Plasma membrane calcium ATPase isoform 4, Plasma membrane calcium pump isoform 4, ATP2B4, ATP2B2, MXRA1
Application Note:
For WB starting dilution is: 1:1000
Background:
The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 4. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq].
Background References:
  • Holton, M., et al. Cardiovasc. Res. 87(3):440-448(2010)
  • Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
  • Juranic, N., et al. J. Biol. Chem. 285(6):4015-4024(2010)
  • Ehret, G.B., et al. Eur. J. Hum. Genet. 17(12):1650-1657(2009)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This ATP2B4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1174-1202 amino acids from the C-terminal region of human ATP2B4.
NCBI Gene ID #:
493
NCBI Official Name:
Plasma membrane calcium-transporting ATPase 4
NCBI Official Symbol:
ATP2B4
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
138 kDa
Protein Accession #:
P23634
Protein GI Number:
14286105
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Signal Transduction
Swissprot #:
P23634
User NOte:
Optimal dilutions for each application to be determined by the researcher.