ProSci

KRT80 Antibody

Product Code:
 
PSI-55-483
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Western blot analysis in NCI-H460,SK-BR-3 cell line lysates (35ug/lane).
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Western blot analysis in NCI-H460,SK-BR-3 cell line lysates (35ug/lane).

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PSI-55-483-400ul400ul£626.00
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Further Information

Additional Names:
Keratin, type II cytoskeletal 80, Cytokeratin-80, CK-80, Keratin-80, K80, Type-II keratin Kb20, KRT80, KB20
Application Note:
For WB starting dilution is: 1:1000
Background:
Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This gene's expression profile shows that it encodes a type II epithelial keratin, although structurally the encoded protein is more like a type II hair keratin. This protein is involved in cell differentiation, localizing near desmosomal plaques in earlier stages of differentiation but then dispersing throughout the cytoplasm in terminally differentiating cells. The type II keratins are clustered in a region of chromosome 12q13. Two transcript variants encoding two different fully functional isoforms have been found for this gene.
Background References:
  • Langbein, L., et al. J. Biol. Chem. 285(47):36909-36921(2010)
  • Lamesch, P., et al. Genomics 89(3):307-315(2007)
  • Schweizer, J., et al. J. Cell Biol. 174(2):169-174(2006)
  • Rogers, M.A., et al. J. Invest. Dermatol. 124(3):536-544(2005)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This KRT80 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 404-432 amino acids from the C-terminal region of human KRT80.
NCBI Gene ID #:
144501
NCBI Official Name:
Keratin, type II cytoskeletal 80
NCBI Official Symbol:
KRT80
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
51 kDa
Protein Accession #:
Q6KB66
Protein GI Number:
166218808
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Signal Transduction
Swissprot #:
Q6KB66
User NOte:
Optimal dilutions for each application to be determined by the researcher.