ProSci

NPLOC4 Antibody

Product Code:
 
PSI-59-142
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Western blot analysis in CEM cell line lysates (35ug/lane).
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Western blot analysis in CEM cell line lysates (35ug/lane).

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PSI-59-142-400ul400ul£626.00
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Further Information

Additional Names:
Nuclear protein localization protein 4 homolog, Protein NPL4, NPLOC4, KIAA1499, NPL4
Application Note:
For WB starting dilution is: 1:1000
Background:
The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity).
Background References:
  • Liu, F., et al. PLoS Genet. 6, E1000934 (2010) :
  • Lass, A., et al. Exp. Cell Res. 314(14):2715-2723(2008)
  • McConnell, E., et al. Biochem. Biophys. Res. Commun. 355(4):1087-1090(2007)
  • Gevaert, K., et al. Nat. Biotechnol. 21(5):566-569(2003)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Mouse, Rat
Immunogen:
This NPLOC4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 456-484 amino acids from the C-terminal region of human NPLOC4.
NCBI Gene ID #:
55666
NCBI Official Name:
Nuclear protein localization protein 4 homolog
NCBI Official Symbol:
NPLOC4
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
68 kDa
Protein Accession #:
Q8TAT6
Protein GI Number:
50428974
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Signal Transduction
Swissprot #:
Q8TAT6
User NOte:
Optimal dilutions for each application to be determined by the researcher.