ProSci

BLOC1S3 Antibody

Product Code:
 
PSI-60-771
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Western blot analysis in A2058 cell line lysates (35ug/lane).

Western blot analysis in A2058 cell line lysates (35ug/lane).

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PSI-60-771-400ul400ul£626.00
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Further Information

Additional Names:
Biogenesis of lysosome-related organelles complex 1 subunit 3, BLOC-1 subunit 3, BLOC1S3, BLOS3
Application Note:
For WB starting dilution is: 1:1000
Background:
This gene encodes a protein that is a component of the BLOC1 multi-subunit protein complex. This complex is necessary for the biogenesis of specialized organelles of the endosomal-lysosomal system, including platelet dense granules and melanosomes. Mutations in this gene cause Hermansky-Pudlak syndrome 8, a disease characterized by lysosomal storage defects, bleeding due to platelet storage pool deficiency, and oculocutaneous albinism.
Background References:
  • Seshadri, S., et al. JAMA 303(18):1832-1840(2010)
  • Lowe, J.K., et al. PLoS Genet.(2), E1000365 (2009) :
  • Olsen, J.V., et al. Cell 127(3):635-648(2006)
  • Morgan, N.V., et al. Am. J. Hum. Genet. 78(1):160-166(2006)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This BLOC1S3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 176-202 amino acids from the C-terminal region of human BLOC1S3.
NCBI Gene ID #:
388552
NCBI Official Name:
Biogenesis of lysosome-related organelles complex 1 subunit 3
NCBI Official Symbol:
BLOC1S3
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
21 kDa
Protein Accession #:
Q6QNY0
Protein GI Number:
74749299
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Signal Transduction
Swissprot #:
Q6QNY0
User NOte:
Optimal dilutions for each application to be determined by the researcher.