ProSci

DBNL Antibody

Product Code:
 
PSI-58-815
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Western blot analysis in HL-60 cell line lysates (35ug/lane).
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Western blot analysis in HL-60 cell line lysates (35ug/lane).

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PSI-58-815-400ul400ul£626.00
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Further Information

Additional Names:
Drebrin-like protein, Cervical SH3P7, Cervical mucin-associated protein, Drebrin-F, HPK1-interacting protein of 55 kDa, HIP-55, SH3 domain-containing protein 7, DBNL, CMAP, SH3P7
Application Note:
For WB starting dilution is: 1:1000
Background:
Actin-binding adapter protein. May act as a common effector of antigen receptor-signaling pathways in leukocytes. Its association with dynamin suggests that it may also connect the actin cytoskeleton to endocytic function. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes. Binds to F-actin but is not involved in actin polymerization, capping or bundling. Does not bind G-actin.
Background References:
  • Venkatesan, K., et al. Nat. Methods 6(1):83-90(2009)
  • Haeckel, A., et al. J. Neurosci. 28(40):10031-10044(2008)
  • Le Bras, S., et al. FEBS Lett. 581(5):967-974(2007)
  • Lamesch, P., et al. Genomics 89(3):307-315(2007)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This DBNL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 292-319 amino acids from the C-terminal region of human DBNL.
NCBI Gene ID #:
28988
NCBI Official Name:
Drebrin-like protein
NCBI Official Symbol:
DBNL
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
48 kDa
Protein Accession #:
Q9UJU6
Protein GI Number:
51316115
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Signal Transduction
Swissprot #:
Q9UJU6
User NOte:
Optimal dilutions for each application to be determined by the researcher.