ProSci

PDZD3 Antibody

Product Code:
 
PSI-59-347
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Western blot analysis in ZR-75-1 cell line lysates (35ug/lane).
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Western blot analysis in ZR-75-1 cell line lysates (35ug/lane).

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PSI-59-347-400ul400ul£626.00
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Further Information

Additional Names:
Na(+)/H(+) exchange regulatory cofactor NHE-RF4, NHERF-4, Intestinal and kidney-enriched PDZ protein, Natrium-phosphate cotransporter IIa C-terminal-associated protein 2, Na/Pi cotransporter C-terminal-associated protein 2, NaPi-Cap2, PDZ domain-containing protein 2, PDZ domain-containing protein 3, Sodium-hydrogen exchanger regulatory factor 4, PDZD3, IKEPP, NHERF4, PDZK2
Application Note:
For WB starting dilution is: 1:1000
Background:
Guanylyl cyclase C (GCC, or GUCY2C; MIM 601330) produces cGMP following the binding of either endogenous ligands or heat-stable enterotoxins secreted by E. coli and other enteric bacteria. Activation of GCC initiates a signaling cascade that leads to phosphorylation of the cystic fibrosis transmembrane conductance regulator (CFTR; MIM 602421), followed by a net efflux of ions and water into the intestinal lumen. IKEPP is a regulatory protein that associates with GCC and regulates the amount of cGMP produced following receptor stimulation (Scott et al., 2002 [PubMed 11950846]).
Background References:
  • Zachos, N.C., et al. Cell. Physiol. Biochem. 22 (5-6), 693-704 (2008) :
  • Kato, Y., et al. Mol. Pharmacol. 67(3):734-743(2005)
  • Hegedus, T., et al. Biochem. Biophys. Res. Commun. 302(3):454-461(2003)
  • Scott, R.O., et al. J. Biol. Chem. 277(25):22934-22941(2002)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This PDZD3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 258-285 amino acids from the Central region of human PDZD3.
NCBI Gene ID #:
79849
NCBI Official Name:
Na(+)/H(+) exchange regulatory cofactor NHE-RF4
NCBI Official Symbol:
PDZD3
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
61 kDa
Protein Accession #:
Q86UT5
Protein GI Number:
308153467
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Signal Transduction
Swissprot #:
Q86UT5
User NOte:
Optimal dilutions for each application to be determined by the researcher.