ProSci

HSPBP1 Antibody

Product Code:
 
PSI-57-976
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Immunohistochemistry- Paraffin Embedded (IHC-P)
  • Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Western blot analysis in Jurkat cell line lysates (35ug/lane).
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HSPBP1 Antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human heart tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.
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Western blot analysis in Jurkat cell line lysates (35ug/lane).
HSPBP1 Antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human heart tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.

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PSI-57-976-400ul400ul£626.00
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Further Information

Additional Names:
Hsp70-binding protein 1, HspBP1, Heat shock protein-binding protein 1, Hsp70-binding protein 2, HspBP2, Hsp70-interacting protein 1, Hsp70-interacting protein 2, HSPBP1, HSPBP
Application Note:
For WB starting dilution is: 1:1000

For IHC-P starting dilution is: 1:10~50
Background:
HSPBP1 inhibits HSPA1A chaperone activity by changing the conformation of the ATP-binding domain of HSPA1A and interfering with ATP binding. Interferes with ubiquitination mediated by STUB1 and inhibits chaperone-assisted degradation of immature CFTR.
Background References:
  • Graner, M.W., et al. Cancer Sci. 100(10):1870-1879(2009)
  • Evdonin, A., et al. Biol. Cell 101(6):351-360(2009)
  • Souza, A.P., et al. Cell Stress Chaperones 14(3):301-310(2009)
  • Howarth, J.L., et al. J. Neurochem. 108(4):945-951(2009)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Monkey, Mouse, Rat
Immunogen:
This HSPBP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 69-97 amino acids from the N-terminal region of human HSPBP1.
NCBI Gene ID #:
23640
NCBI Official Name:
Hsp70-binding protein 1
NCBI Official Symbol:
HSPBP1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
39 kDa
Protein Accession #:
Q9NZL4
Protein GI Number:
74734730
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Signal Transduction
Swissprot #:
Q9NZL4
User NOte:
Optimal dilutions for each application to be determined by the researcher.