Further Information
ER lumen protein-retaining receptor 2, ERD2-like protein 1, ELP-1, KDEL endoplasmic reticulum protein retention receptor 2, KDEL receptor 2, KDELR2, ERD22
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
Retention of resident soluble proteins in the lumen of the
endoplasmic reticulum (ER) is achieved in both yeast and animal
cells by their continual retrieval from the cis-Golgi, or a
pre-Golgi compartment. Sorting of these proteins is dependent on a
C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in
animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This
process is mediated by a receptor that recognizes, and binds the
tetrapeptide-containing protein, and returns it to the ER. In
yeast, the sorting receptor encoded by a single gene, ERD2, is a
seven-transmembrane protein. Unlike yeast, several human homologs
of the ERD2 gene, constituting the KDEL receptor gene family, have
been described. KDELR2 was the second member of the family to be
identified, and it encodes a protein which is 83% identical to the
KDELR1 gene product. Alternative splicing results in multiple
transcript variants encoding distinct isoforms. [provided by
RefSeq].
- van der Vlies, D., et al. Biochem. J. 366 (PT 3), 825-830 (2002) :
- Pelham, H.R. Cell Struct. Funct. 21(5):413-419(1996)
- Lewis, M.J., et al. J. Mol. Biol. 226(4):913-916(1992)
- Hsu, V.W., et al. Cell 69(4):625-635(1992)
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Predicted species reactivity based on immunogen sequence: Xenopus, Bovine, Mouse, Rat
This KDELR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 183-211 amino acids from the C-terminal region of human KDELR2.
11014
ER lumen protein-retaining receptor 2
KDELR2
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
24 kDa
P33947
462018
This antibody is purified through a protein A column, followed by peptide affinity purification.
Signal Transduction
P33947
Optimal dilutions for each application to be determined by the researcher.