Further Information
Gap junction gamma-1 protein, Connexin-45, Cx45, Gap junction alpha-7 protein, GJC1, GJA7
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:50~100
Gap junctions were first characterized by electron microscopy as regionally specialized structures on plasma membranes of contacting adherent cells. These structures were shown to consist of cell-to-cell closely packed transmembrane channels. Proteins, called connexins, purified from fractions of enriched gap junctions from different tissues differ. Connexins are designated by their molecular mass. Another system of nomenclature divides gap junction proteins into 2 categories, alpha and beta, according to sequence similarities at the nucleotide and amino acid levels. For example, CX43 is designated alpha-1 gap junction protein, whereas CX32 and CX26 are called beta-1 and beta-2 gap junction proteins, respectively. This nomenclature emphasizes that CX32 and CX26 are more homologous to each other than either of them is to CX43. Connexins have four transmembrane, three intracellular, and two extracellular regions. Different tissues express different connexins, though tissue specificities overlap, and a given tissue or cell can express several different connexins. Developmental regulation of at least some of the connexin genes has been found. Embryo implantation is regulated in part by temporally changing patterns of expression of connexins in the embryo and the maternal decidua.
- Xiang, Q., et al., Ai Zheng 21(6):593-596 (2002).
- Kanter, H.L., et al., J. Mol. Cell. Cardiol. 26(7):861-868 (1994).
- Kaba, R.A., et al., Cell Commun. Adhes.(4-6), 339-343 (2001).
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Predicted species reactivity based on immunogen sequence: Hamster, Mouse, Pig, Rat
This GJA7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 89-120 amino acids from the N-terminal region of human GJA7.
10052
Gap junction gamma-1 protein
GJC1
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
45 kDa
P36383
226693517
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Signal Transduction
P36383
Optimal dilutions for each application to be determined by the researcher.