ProSci

CNOT2 Antibody

Product Code:
 
PSI-57-581
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Western blot analysis in Jurkat cell line lysates (35ug/lane).

Western blot analysis in Jurkat cell line lysates (35ug/lane).

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PSI-57-581-400ul400ul£626.00
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Further Information

Additional Names:
CCR4-NOT transcription complex subunit 2, CCR4-associated factor 2, CNOT2, CDC36, NOT2
Application Note:
For WB starting dilution is: 1:1000
Background:
This gene encodes a subunit of the multi-component CCR4-NOT complex. The CCR4-NOT complex regulates mRNA synthesis and degradation and is also thought to be involved in mRNA splicing, transport and localization. The encoded protein interacts with histone deacetylases and functions as a repressor of polymerase II transcription. Alternatively spliced transcript variants have been observed for this gene.
Background References:
  • Lau, N.C., et al. Biochem. J. 422(3):443-453(2009)
  • Miyasaka, T., et al. Cancer Sci. 99(4):755-761(2008)
  • Morita, M., et al. Mol. Cell. Biol. 27(13):4980-4990(2007)
  • Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Mouse
Immunogen:
This CNOT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 272-301 amino acids from the Central region of human CNOT2.
NCBI Gene ID #:
4848
NCBI Official Name:
CCR4-NOT transcription complex subunit 2
NCBI Official Symbol:
CNOT2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
60 kDa
Protein Accession #:
Q9NZN8
Protein GI Number:
46396017
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Swissprot #:
Q9NZN8
User NOte:
Optimal dilutions for each application to be determined by the researcher.