ProSci

EXOSC4 Antibody

Product Code:
 
PSI-59-063
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Western blot analysis in U251 cell line lysates (35ug/lane).
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Western blot analysis in U251 cell line lysates (35ug/lane).

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PSI-59-063-400ul400ul£626.00
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Further Information

Additional Names:
Exosome complex component RRP41, Exosome component 4, Ribosomal RNA-processing protein 41, p12A, EXOSC4, RRP41, SKI6
Application Note:
For WB starting dilution is: 1:1000
Background:
Component of the exosome 3'->5' exoribonuclease complex, a complex that degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3'-untranslated regions. Required for the 3'-processing of the 7S pre-RNA to the mature 5.8S rRNA. Has a 3'-5' exonuclease activity. Plays a role in replication-dependent histone mRNA degradation.
Background References:
  • Mullen, T.E., et al. Genes Dev. 22(1):50-65(2008)
  • van Dijk, E.L., et al. RNA 13(7):1027-1035(2007)
  • Oh, J.H., et al. Mamm. Genome 16(12):942-954(2005)
  • Andersen, J.S., et al. Nature 433(7021):77-83(2005)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine, Mouse
Immunogen:
This EXOSC4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 69-96 amino acids from the Central region of human EXOSC4.
NCBI Gene ID #:
54512
NCBI Official Name:
Exosome complex component RRP41
NCBI Official Symbol:
EXOSC4
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
26 kDa
Protein Accession #:
Q9NPD3
Protein GI Number:
14285756
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Swissprot #:
Q9NPD3
User NOte:
Optimal dilutions for each application to be determined by the researcher.