ProSci

SPOP Antibody

Product Code:
 
PSI-60-100
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Western blot analysis in WiDr cell line lysates (35ug/lane).
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Western blot analysis in WiDr cell line lysates (35ug/lane).

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PSI-60-100-400ul400ul£626.00
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Further Information

Additional Names:
Speckle-type POZ protein, HIB homolog 1, Roadkill homolog 1, SPOP
Application Note:
For WB starting dilution is: 1:1000
Background:
This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq].
Background References:
  • Rose, J. Phd, et al. Mol. Med. (2010) In press :
  • Zhuang, M., et al. Mol. Cell 36(1):39-50(2009)
  • Liu, J., et al. Science 323(5918):1218-1222(2009)
  • Bunce, M.W., et al. J. Biol. Chem. 283(13):8678-8686(2008)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Xenopus, Bovine, Zebrafish, Mouse
Immunogen:
This SPOP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 86-115 amino acids from the N-terminal region of human SPOP.
NCBI Gene ID #:
8405
NCBI Official Name:
Speckle-type POZ protein
NCBI Official Symbol:
SPOP
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
42 kDa
Protein Accession #:
O43791
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Swissprot #:
O43791
User NOte:
Optimal dilutions for each application to be determined by the researcher.