ProSci

CENPA Antibody

Product Code:
 
PSI-57-304
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Western blot analysis in Jurkat cell line lysates (35ug/lane).
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Western blot analysis in Jurkat cell line lysates (35ug/lane).

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PSI-57-304-400ul400ul£626.00
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Further Information

Additional Names:
Histone H3-like centromeric protein A, Centromere autoantigen A, Centromere protein A, CENP-A, CENPA
Application Note:
For WB starting dilution is: 1:1000
Background:
Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. CENPA encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. CENPA is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq].
Background References:
  • Sekulic, N., et al. Nature 467(7313):347-351(2010)
  • Carroll, C.W., et al. J. Cell Biol. 189(7):1143-1155(2010)
  • Maehara, K., et al. Mol. Cell. Biol. 30(9):2090-2104(2010)
  • Buscaino, A., et al. Curr. Opin. Genet. Dev. 20(2):118-126(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine, Hamster
Immunogen:
This CENPA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 82-110 amino acids from the Central region of human CENPA.
NCBI Gene ID #:
1058
NCBI Official Name:
Histone H3-like centromeric protein A
NCBI Official Symbol:
CENPA
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
16 kDa
Protein Accession #:
P49450
Protein GI Number:
1345726
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Swissprot #:
P49450
User NOte:
Optimal dilutions for each application to be determined by the researcher.