ProSci

SSRP1 Antibody

Product Code:
 
PSI-58-023
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Western blot analysis in CEM cell line lysates (35ug/lane).
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Western blot analysis in CEM cell line lysates (35ug/lane).

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PSI-58-023-400ul400ul£626.00
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Further Information

Additional Names:
FACT complex subunit SSRP1, Chromatin-specific transcription elongation factor 80 kDa subunit, Facilitates chromatin transcription complex 80 kDa subunit, FACT 80 kDa subunit, FACTp80, Facilitates chromatin transcription complex subunit SSRP1, Recombination signal sequence recognition protein 1, Structure-specific recognition protein 1, hSSRP1, T160, SSRP1, FACT80
Application Note:
For WB starting dilution is: 1:1000
Background:
The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63. An alternatively spliced transcript variant of this gene has been described, but its full-length nature is not known.
Background References:
  • Zeng, S.X., et al. Mol. Cell. Biol. 30(4):935-947(2010)
  • Hautbergue, G.M., et al. Curr. Biol. 19(22):1918-1924(2009)
  • Hu, J., et al. J. Virol. 83(21):11051-11063(2009)
  • Kumari, A., et al. J. Cell. Biochem. 108(2):508-518(2009)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This SSRP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 490-518 amino acids from the C-terminal region of human SSRP1.
NCBI Gene ID #:
6749
NCBI Official Name:
FACT complex subunit SSRP1
NCBI Official Symbol:
SSRP1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
81 kDa
Protein Accession #:
Q08945
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Swissprot #:
Q08945
User NOte:
Optimal dilutions for each application to be determined by the researcher.