Further Information
Protein arginine N-methyltransferase 5, 211-, 72 kDa ICln-binding protein, Histone-arginine N-methyltransferase PRMT5, Jak-binding protein 1, Shk1 kinase-binding protein 1 homolog, SKB1 homolog, SKB1Hs, Protein arginine N-methyltransferase 5, N-terminally processed, PRMT5, HRMT1L5, IBP72, JBP1, SKB1
For WB starting dilution is: 1:1000
Arginine methylation is an irreversible post translational modification which has only recently been linked to protein activity. At least three types of PRMT enzymes have been identified in mammalian cells. These enzymes have been shown to have essential regulatory functions by methylation of key proteins in several fundamental areas. These protein include nuclear proteins, IL enhancer binding factor, nuclear factors, cell cycle proteins, signal transduction proteins, apoptosis proteins, and viral proteins. The mammalian PRMT family currently consists of 7 members that share two large domains of homology. Outside of these domains, epitopes were identified and antibodies against all 7 PRMT members have been developed.
- Pal, S., et al., Mol. Cell. Biol. 23(21):7475-7487 (2003).
- Rho, J., et al., J. Biol. Chem. 276(14):11393-11401 (2001).
- Pollack, B.P., et al., J. Biol. Chem. 274(44):31531-31542 (1999).
- Gilbreth, M., et al., Proc. Natl. Acad. Sci. U.S.A. 95(25):14781-14786 (1998).
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Predicted species reactivity based on immunogen sequence: Bovine, Monkey, Mouse, Xenopus
This PRMT5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 473-499 amino acids from the C-terminal region of human PRMT5.
10419
Protein arginine N-methyltransferase 5
PRMT5
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
73 kDa
O14744
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
O14744
Optimal dilutions for each application to be determined by the researcher.