ProSci

NME1 Antibody

Product Code:
 
PSI-58-112
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Western blot analysis in Hela,NCI-H460 cell line lysates (35ug/lane).
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Western blot analysis in Hela,NCI-H460 cell line lysates (35ug/lane).

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PSI-58-112-400ul400ul£626.00
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Further Information

Additional Names:
Nucleoside diphosphate kinase A, NDK A, NDP kinase A, Granzyme A-activated DNase, GAAD, Metastasis inhibition factor nm23, NM23-H1, Tumor metastatic process-associated protein, NME1, NDPKA, NM23
Application Note:
For WB starting dilution is: 1:1000
Background:
This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product.
Background References:
  • Boissan, M., et al. Cancer Res. 70(19):7710-7722(2010)
  • Wang, P.H., et al. Gynecol. Oncol. 119(1):70-75(2010)
  • Conery, A.R., et al. Proc. Natl. Acad. Sci. U.S.A. 107(35):15461-15466(2010)
  • Wang, Z., et al. Med. Sci. Monit. 16 (8), CR357-CR364 (2010) :
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Rat
Immunogen:
This NME1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 103-131 amino acids from the C-terminal region of human NME1.
NCBI Gene ID #:
4830
NCBI Official Name:
Nucleoside diphosphate kinase A
NCBI Official Symbol:
NME1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
17 kDa
Protein Accession #:
P15531
Protein GI Number:
127981
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Swissprot #:
P15531
User NOte:
Optimal dilutions for each application to be determined by the researcher.