ProSci

NACC2 Antibody

Product Code:
 
PSI-58-673
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Western blot analysis in A2058 cell line lysates (35ug/lane).
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Western blot analysis in A2058 cell line lysates (35ug/lane).

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PSI-58-673-400ul400ul£626.00
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Further Information

Additional Names:
Nucleus accumbens-associated protein 2, NAC-2, BTB/POZ domain-containing protein 14A, Repressor with BTB domain and BEN domain, NACC2, BTBD14A, NAC2, RBB
Application Note:
For WB starting dilution is: 1:1000
Background:
BTBD14A (BTB/POZ domain-containing protein 14A), also known as BTBD14, is a 587 amino acid protein that contains one BTB/POZ domain. The BTB/POZ domain mediates homomeric and heteromeric POZ-POZ interactions and is common to transcriptional regulators involved in chromatin modeling. In several BTB/POZ containing proteins, including BCL-6 and the promyelocytic leukemia zinc-finger (PLZF) oncoprotein, this domain interacts with the SMRT/N-CoR-mSin3A HDAC complex and is directly involved in repressing and silencing gene transcription. When this domain is deleted, as with the oncogenic PLZF-RAR chimera of promyelocytic leukemias, this transcriptional repression is attenuated. This suggests that BTBD14A may play a role in transcription regulation.
Background References:
  • Rose, J. Phd, et al. Mol. Med. (2010) In press :
  • Humphray, S.J., et al. Nature 429(6990):369-374(2004)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This NACC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 473-502 amino acids from the C-terminal region of human NACC2.
NCBI Gene ID #:
138151
NCBI Official Name:
Nucleus accumbens-associated protein 2
NCBI Official Symbol:
NACC2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
63 kDa
Protein Accession #:
Q96BF6
Protein GI Number:
74751767
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Swissprot #:
Q96BF6
User NOte:
Optimal dilutions for each application to be determined by the researcher.