ProSci

XPC Antibody

Product Code:
 
PSI-60-674
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Western Blot at 1:2000 dilution Lane 1: Hela whole cell lysate Lane 2: MCF-7 whole cell lysate Lane 3: ZR-75-1 whole cell lysate Lysates/proteins at 20 ug per lane.
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Western Blot at 1:2000 dilution Lane 1: Hela whole cell lysate Lane 2: MCF-7 whole cell lysate Lane 3: ZR-75-1 whole cell lysate Lysates/proteins at 20 ug per lane.

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PSI-60-674-400ul400ul£626.00
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Further Information

Additional Names:
DNA repair protein complementing XP-C cells, Xeroderma pigmentosum group C-complementing protein, p125, XPC, XPCC
Application Note:
For WB starting dilution is: 1:2000
Background:
This gene encodes a component of the nucleotide excision repair (NER) pathway. There are multiple components involved in the NER pathway, including Xeroderma pigmentosum (XP) A-G and V, Cockayne syndrome (CS) A and B, and trichothiodystrophy (TTD) group A, etc. This component, XPC, plays an important role in the early steps of global genome NER, especially in damage recognition, open complex formation, and repair protein complex formation. Mutations in this gene or some other NER components result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene.
Background References:
  • Gangwar, R., et al. J. Cancer Res. Clin. Oncol. (2009) In press :
  • Agalliu, I., et al. Cancer Causes Control (2009) In press :
  • Langie, S.A., et al. Br. J. Nutr., 1-12 (2009) In press :
  • Young, R.P., et al. Postgrad Med85(1008):515-524(2009)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This XPC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 154-183 amino acids from the N-terminal region of human XPC.
NCBI Gene ID #:
7508
NCBI Official Name:
DNA repair protein complementing XP-C cells
NCBI Official Symbol:
XPC
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
106 kDa
Protein Accession #:
Q01831
Protein GI Number:
296453081
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Swissprot #:
Q01831
User NOte:
Optimal dilutions for each application to be determined by the researcher.