ProSci

MCM7 Antibody

Product Code:
 
PSI-58-402
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Western blot analysis in Jurkat cell line lysates (35ug/lane).
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Western blot analysis in Jurkat cell line lysates (35ug/lane).

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PSI-58-402-400ul400ul£626.00
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Further Information

Additional Names:
DNA replication licensing factor MCM7, CDC47 homolog, P11-MCM3, MCM7, CDC47, MCM2
Application Note:
For WB starting dilution is: 1:1000
Background:
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
Background References:
  • Lau, K.M., et al. Oncogene 29(40):5475-5489(2010)
  • Kim, D.W., et al. Mol. Biochem. Parasitol. 173(1):10-16(2010)
  • Olson, J.E., et al. Breast Cancer Res. Treat. (2010) In press :
  • Rojiani, M.V., et al. Appl. Immunohistochem. Mol. Morphol. 18(3):278-282(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This MCM7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 290-318 amino acids from the N-terminal region of human MCM7.
NCBI Gene ID #:
4176
NCBI Official Name:
DNA replication licensing factor MCM7
NCBI Official Symbol:
MCM7
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
81 kDa
Protein Accession #:
P33993
Protein GI Number:
20981696
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Swissprot #:
P33993
User NOte:
Optimal dilutions for each application to be determined by the researcher.