ProSci

RRM1 Antibody

Product Code:
 
PSI-60-858
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Western blot analysis in A549 cell line lysates (35ug/lane).
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Western blot analysis in A549 cell line lysates (35ug/lane).

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PSI-60-858-400ul400ul£626.00
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Further Information

Additional Names:
Ribonucleoside-diphosphate reductase large subunit, Ribonucleoside-diphosphate reductase subunit M1, Ribonucleotide reductase large subunit, RRM1, RR1
Application Note:
For WB starting dilution is: 1:1000
Background:
This gene encodes one of two non-identical subunits that constitute ribonucleoside-diphosphate reductase, an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region.
Background References:
  • Ucisik-Akkaya, E., et al. Mol. Hum. Reprod. 16(10):770-777(2010)
  • Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)
  • Vinolas, N., et al. Lung Cancer (2010) In press :
  • Niida, H., et al. Genes Dev. 24(4):333-338(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Mouse
Immunogen:
This RRM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 71-100 amino acids from the N-terminal region of human RRM1.
NCBI Gene ID #:
6240
NCBI Official Name:
Ribonucleoside-diphosphate reductase large subunit
NCBI Official Symbol:
RRM1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
90 kDa
Protein Accession #:
P23921
Protein GI Number:
132608
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Swissprot #:
P23921
User NOte:
Optimal dilutions for each application to be determined by the researcher.