Further Information
Histone-lysine N-methyltransferase NSD2, Multiple myeloma SET domain-containing protein, MMSET, Nuclear SET domain-containing protein 2, NSD2, Protein trithorax-5, Wolf-Hirschhorn syndrome candidate 1 protein, WHSC1, WHSC1, KIAA1090, MMSET, NSD2, TRX5
For WB starting dilution is: 1:1000
This gene encodes a protein that contains four domains
present in other developmental proteins: a PWWP domain, an HMG box,
a SET domain, and a PHD-type zinc finger. It is expressed
ubiquitously in early development. Wolf-Hirschhorn syndrome (WHS)
is a malformation syndrome associated with a hemizygous deletion of
the distal short arm of chromosome 4. This gene maps to the 165 kb
WHS critical region and has also been involved in the chromosomal
translocation t(4;14)(p16.3;q32.3) in multiple myelomas.
Alternative splicing of this gene results in multiple transcript
variants encoding different isoforms. Some transcript variants are
nonsense-mediated mRNA (NMD) decay candidates, hence not
represented as reference sequences.
- Jugessur, A., et al. PLoS ONE(7), E11493 (2010) :
- Kang, H.B., et al. FEBS Lett. 583(12):1880-1886(2009)
- Kassambara, A., et al. Biochem. Biophys. Res. Commun. 379(4):840-845(2009)
- Brito, J.L., et al. Haematologica 94(1):78-86(2009)
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Predicted species reactivity based on immunogen sequence: Mouse
This WHSC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1061-1089 amino acids from the C-terminal region of human WHSC1.
7468
Histone-lysine N-methyltransferase NSD2
WHSC1
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
152 kDa
O96028
This antibody is purified through a protein A column, followed by peptide affinity purification.
O96028
Optimal dilutions for each application to be determined by the researcher.