Further Information
Serine/arginine-rich splicing factor 2, Protein PR264, Splicing component, 35 kDa, Splicing factor SC35, SC-35, Splicing factor, arginine/serine-rich 2, SRSF2, SFRS2
For WB starting dilution is: 1:1000
SFRS2 is necessary for the splicing of pre-mRNA. The protein is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA. And it interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. It binds to purine-rich RNA sequences, either 5'-AGSAGAGTA-3' (S=C or G) or 5'-GTTCGAGTA-3' and can bind to beta-globin mRNA and commit it to the splicing pathway.
- Merdzhanova,G., Cell Death Differ. 15 (12), 1815-1823 (2008)
- Solis,A.S., J. Biol. Chem. 283 (35), 23619-23626 (2008)
- Donev,R., Mol. Psychiatry 12 (7), 681-690 (2007)
- Sureau,A., Proc. Natl. Acad. Sci. U.S.A. 89 (24), 11683-11687 (1992)
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Predicted species reactivity based on immunogen sequence: Bovine, Chicken, Mouse, Pig, Rat
This SFRS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 76-105 amino acids from the Central region of human SFRS2.
6427
Serine/arginine-rich splicing factor 2
SRSF2
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
25 kDa
Q01130
60416437
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Q01130
Optimal dilutions for each application to be determined by the researcher.