ProSci

RENT1 Antibody

Product Code:
 
PSI-60-295
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Western blot analysis of RENT1 using rabbit polyclonal RENT1 Antibody using 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the RENT1 gene (Lane 2).
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Western blot analysis of RENT1 using rabbit polyclonal RENT1 Antibody using 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the RENT1 gene (Lane 2).

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PSI-60-295-400ul400ul£626.00
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Further Information

Additional Names:
Regulator of nonsense transcripts 1, 364-, ATP-dependent helicase RENT1, Nonsense mRNA reducing factor 1, NORF1, Up-frameshift suppressor 1 homolog, hUpf1, UPF1, KIAA0221, RENT1
Application Note:
For WB starting dilution is: 1:1000
Background:
RENT1 is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping.
Background References:
  • Ohnishi, T., et al., Mol. Cell 12(5):1187-1200 (2003).
  • Lykke-Andersen, J., Mol. Cell. Biol. 22(23):8114-8121 (2002).
  • Carastro, L.M., et al., Nucleic Acids Res. 30(10):2232-2243 (2002).
  • Mendell, J.T., et al., Science 298(5592):419-422 (2002).
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Mouse
Immunogen:
This RENT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 297-326 amino acids from the N-terminal region of human RENT1.
NCBI Gene ID #:
5976
NCBI Official Name:
Regulator of nonsense transcripts 1
NCBI Official Symbol:
UPF1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
124 kDa
Protein Accession #:
Q92900
Protein GI Number:
17380291
Purification:
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Swissprot #:
Q92900
User NOte:
Optimal dilutions for each application to be determined by the researcher.