ProSci

EXOSC8 Antibody

Product Code:
 
PSI-61-502
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Fluorescence-activated cell sorting (FACS)
  • Immunohistochemistry- Paraffin Embedded (IHC-P)
  • Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Western blot analysis of anti-EXOSC8 Antibody in HL60 cell line lysates (35ug/lane).
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Formalin-fixed and paraffin-embedded human brain tissue with EXOSC8 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
3 / 3
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Western blot analysis of anti-EXOSC8 Antibody in HL60 cell line lysates (35ug/lane).
Formalin-fixed and paraffin-embedded human brain tissue with EXOSC8 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.

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PSI-61-502-400ul400ul£626.00
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Further Information

Additional Names:
Exosome complex component RRP43, Exosome component 8, Opa-interacting protein 2, OIP-2, Ribosomal RNA-processing protein 43, p9, EXOSC8, OIP2, RRP43
Application Note:
For WB starting dilution is: 1:1000

For IHC-P starting dilution is: 1:50~100

For FACS starting dilution is: 1:10~50
Background:
EXOSC8 is a component of the exosome 3'->5' exoribonuclease complex, a complex that degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3'-untranslated regions. It is required for the 3'-processing of the 7S pre-RNA to the mature 5.8S rRNA and has a 3'-5' exonuclease activity.
Background References:
  • Raijmakers,R., J. Mol. Biol. 323 (4), 653-663 (2002)
  • Jiang,T., Proc. Natl. Acad. Sci. U.S.A. 99 (8), 5295-5300 (2002)
  • Raijmakers,R., J. Mol. Biol. 315 (4), 809-818 (2002)
  • Brouwer,R., J. Biol. Chem. 276 (9), 6177-6184 (2001)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This EXOSC8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 243-276 amino acids from the C-terminal region of human EXOSC8.
NCBI Gene ID #:
11340
NCBI Official Name:
Exosome complex component RRP43
NCBI Official Symbol:
EXOSC8
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
30 kDa
Protein Accession #:
Q96B26
Protein GI Number:
21759409
Purification:
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Swissprot #:
Q96B26
User NOte:
Optimal dilutions for each application to be determined by the researcher.