ProSci

GGPS1 Antibody

Product Code:
 
PSI-61-392
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
Applications:
  • Immunohistochemistry- Paraffin Embedded (IHC-P)
  • Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Western blot analysis ofGGPS1 Antibody in mouse cerbellum tissue lysates (35ug/lane)
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Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with GGPS1 Antibody (AP2419b), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
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Western blot analysis ofGGPS1 Antibody in mouse cerbellum tissue lysates (35ug/lane)
Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with GGPS1 Antibody (AP2419b), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.

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PSI-61-392-400ul400ul£626.00
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Further Information

Additional Names:
Geranylgeranyl pyrophosphate synthase, GGPP synthase, GGPPSase, 251-, (2E,6E)-farnesyl diphosphate synthase, Dimethylallyltranstransferase, Farnesyl diphosphate synthase, Farnesyltranstransferase, Geranylgeranyl diphosphate synthase, Geranyltranstransferase, GGPS1
Application Note:
For WB starting dilution is: 1:1000

For IHC-P starting dilution is: 1:50~100
Background:
Geranylgeranyl diphosphate (GGPP) synthase (GGPS) catalyzes the synthesis of GGPP, a molecule responsible for the C20-prenylation of protein and for the regulation of a nuclear hormone receptor. The deduced 300-amino acid human protein contains 5 conserved domains consistent with prenyltransferases. Recombinant GGPS shows enzymatic properties associated with the synthesis of GGPP from farnesyl diphosphate and isopentenyl diphosphate. Mouse GGPS is regulated in several tissues in obesity and is induced during adipocyte differentiation. GGPS is increased 5- to 20-fold in skeletal muscle, liver, and fat of ob/ob mice. Western blot analysis detects a 2-fold overexpression of protein in muscle and fat but not in liver. Differentiation of mouse fibroblasts into adipocytes induces GGPS expression more than 20-fold.
Background References:
  • Kainou, T., et al., Biochim. Biophys. Acta 1437(3):333-340 (1999).
  • Kuzuguchi, T., et al., J. Biol. Chem. 274(9):5888-5894 (1999).
  • Ericsson, J., et al., J. Lipid Res. 39(9):1731-1739 (1998).
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This GGPS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 270-300 amino acids from the C-terminal region of human GGPS1.
NCBI Gene ID #:
9453
NCBI Official Name:
Geranylgeranyl pyrophosphate synthase
NCBI Official Symbol:
GGPS1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
35 kDa
Protein Accession #:
O95749
Purification:
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Research Area:
Cancer,Cell Cycle,Obesity
Swissprot #:
O95749
User NOte:
Optimal dilutions for each application to be determined by the researcher.