Further Information
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform, PHK-gamma-LT, PHK-gamma-T, PSK-C3, Phosphorylase kinase subunit gamma-2, PHKG2
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:50~100
Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The STE group (homologs of yeast Sterile 7, 11, 20 kinases) consists of 50 kinases related to the mitogen-activated protein kinase (MAPK) cascade families (Ste7/MAP2K, Ste11/MAP3K, and Ste20/MAP4K). MAP kinase cascades, consisting of a MAPK and one or more upstream regulatory kinases (MAPKKs) have been best characterized in the yeast pheromone response pathway. Pheromones bind to Ste cell surface receptors and activate yeast MAPK pathway.
- Burwinkel, B., et al., Hum. Mol. Genet. 7(1):149-154 (1998). Maichele, A.J., et al., Nat. Genet. 14(3):337-340 (1996). Whitmore, S.A., et al., Genomics 20(2):169-175 (1994). Hanks, S.K., Mol. Endocrinol. 3(1):110-116 (1989). Hanks, S.K., Proc. Natl. Acad. Sci. U.S.A. 84(2):388-392 (1987).
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
This PHKG2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 304-334 amino acids from the Central region of human PHKG2.
5261
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform
PHKG2
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
46 kDa
P15735
125536
This antibody is purified through a protein A column, followed by peptide affinity purification.
Cancer,Signal Transduction
P15735
Optimal dilutions for each application to be determined by the researcher.