ProSci

CCNF Antibody

Product Code:
 
PSI-59-800
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
Application:
 
Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
1 / 2
Western blot analysis in CEM cell line lysates (35ug/lane).
2 / 2
Western blot analysis in mouse liver tissue lysates (35ug/lane).
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Western blot analysis in CEM cell line lysates (35ug/lane).
Western blot analysis in mouse liver tissue lysates (35ug/lane).

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PSI-59-800-400ul400ul£626.00
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Further Information

Additional Names:
Cyclin-F, F-box only protein 1, CCNF, FBX1, FBXO1
Application Note:
For WB starting dilution is: 1:1000
Background:
This gene encodes a member of the cyclin family. Cyclins are important regulators of cell cycle transitions through their ability to bind and activate cyclin-dependent protein kinases. This member also belongs to the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it was one of the first proteins in which the F-box motif was identified.
Background References:
  • D'Angiolella, V., et al. Nature 466(7302):138-142(2010)
  • Fung, T.K., et al. J. Biol. Chem. 277(38):35140-35149(2002)
  • Kong, M., et al. EMBO J. 19(6):1378-1388(2000)
  • Bai, C., et al. Cell 86(2):263-274(1996)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This CCNF antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 496-524 amino acids from the Central region of human CCNF.
NCBI Gene ID #:
899
NCBI Official Name:
Cyclin-F
NCBI Official Symbol:
CCNF
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
88 kDa
Protein Accession #:
P41002
Protein GI Number:
20178283
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Cell Cycle
Swissprot #:
P41002
User NOte:
Optimal dilutions for each application to be determined by the researcher.