ProSci

TLK2 Antibody

Product Code:
 
PSI-63-398
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
Application:
 
Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Western blot analysis of anti-TLK2 Antibody in mouse testis tissue lysates (35ug/lane)
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Western blot analysis in Y79 cell line lysates (35ug/lane).
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Western blot analysis of anti-TLK2 Antibody in mouse testis tissue lysates (35ug/lane)
Western blot analysis in Y79 cell line lysates (35ug/lane).

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PSI-63-398-400ul400ul£626.00
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Further Information

Additional Names:
Serine/threonine-protein kinase tousled-like 2, HsHPK, PKU-alpha, Tousled-like kinase 2, TLK2
Application Note:
For WB starting dilution is: 1:1000
Background:
TLK2, a member of the Ser/Thr protein kinase family, is rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. The TLK2 enzyme is cell-cycle regulated, with maximal activity in S-phase. It is inactivated by phosphorylation at Ser-750, potentially by CHK1. TLK2 heterodimerizes with TLK1. This nuclear protein is widely expressed, with presence in fetal placenta, liver, kidney, pancreas, heart and skeletal muscle tissues, and in several adult cell lines.
Background References:
  • Groth, A., et al., EMBO J. 22(7):1676-1687 (2003). Strausberg, R.L., et al., Proc. Natl. Acad. Sci. U.S.A. 99(26):16899-16903 (2002). Sillje, H.H., et al., EMBO J. 18(20):5691-5702 (1999). Yamakawa, A., et al., Gene 202 (1-2), 193-201 (1997).
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This TLK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 141-171 amino acids from the Central region of human TLK2.
NCBI Gene ID #:
11011
NCBI Official Name:
Serine/threonine-protein kinase tousled-like 2
NCBI Official Symbol:
TLK2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
88 kDa
Protein Accession #:
Q86UE8
Protein GI Number:
34222826
Purification:
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Research Area:
Cell Cycle
Swissprot #:
Q86UE8
User NOte:
Optimal dilutions for each application to be determined by the researcher.