Antibody Isotype:
Rabbit Ig
Antibody Clonality:
Polyclonal
Application:
Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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![Antibody is used in Western blot to detect Aurora C in lysates of 293 cells expressing Flag tag (lane 1), Flag-tagged Aurora A (lane 2), Flag-tagged Aurora B (lane 3), and Flag-tagged Aurora C (lane 4). Data is kindly provided by Drs. K. Sasai and S. Sen from the University of Texas MD Anderson Cancer Center (Houston, TX). Antibody is used in Western blot to detect Aurora C in lysates of 293 cells expressing Flag tag (lane 1), Flag-tagged Aurora A (lane 2), Flag-tagged Aurora B (lane 3), and Flag-tagged Aurora C (lane 4). Data is kindly provided by Drs. K. Sasai and S. Sen from the University of Texas MD Anderson Cancer Center (Houston, TX).](https://www.prosci-inc.com/static-images/62-579_1.jpg)
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![Western blot analysis in 293 cell line lysates (35ug/lane). Western blot analysis in 293 cell line lysates (35ug/lane).](https://www.prosci-inc.com/static-images/62-579_2.jpg)
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This product comes from:
United States.
Typical lead time:
14-21 working days.
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Further Information
Aurora kinase C, Aurora 3, Aurora/IPL1-related kinase 3, ARK-3, Aurora-related kinase 3, Aurora/IPL1/Eg2 protein 2, Serine/threonine-protein kinase 13, Serine/threonine-protein kinase aurora-C, AURKC, AIE2, AIK3, AIRK3, ARK3, STK13
For WB starting dilution is: 1:1000
Chromosomal segregation during mitosis as well as meiosis is regulated by kinases and phosphatases. The Aurora kinases, members of the Ser/Thr protein kinase family, associate with microtubules during chromosome movement and segregation. Aurora kinase C may play a part in organizing microtubules in relation to the function of the centrosome/spindle pole during mitosis. This protein is localized to centrosome from anaphase to cytokinesis. Expression is limited to testis in normal cells. Elevated expression levels are seen only in a subset of cancer cells such as HepG2, HuH7 and HeLa cells. Aurora-C expression is maximum at M phase.
- Kimura, M., et al., J. Biol. Chem. 274(11):7334-7340 (1999).
- Tseng, T.C., et al., DNA Cell Biol. 17(10):823-833 (1998).
- Bernard, M., et al., Genomics 53(3):406-409 (1998).
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
This Aurora-C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 115-145 amino acids from the Central region of human Aurora-C.
6795
Aurora kinase C
AURKC
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
36 kDa
Q9UQB9
27805738
This antibody is purified through a protein A column, followed by peptide affinity purification.
Cell Cycle
Q9UQB9
Optimal dilutions for each application to be determined by the researcher.