Antibody Isotype:
Rabbit Ig
Antibody Clonality:
Polyclonal
Applications:- Flow Cytometry
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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This product comes from:
United States.
Typical lead time:
14-21 working days.
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- Further Information
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Further Information
Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase, UDP-GlcNAc-2-epimerase/ManAc kinase, UDP-N-acetylglucosamine 2-epimerase (hydrolyzing), UDP-GlcNAc-2-epimerase, Uridine diphosphate-N-acetylglucosamine-2-epimerase, N-acetylmannosamine kinase, ManAc kinase, GNE, GLCNE
For WB starting dilution is: 1:1000
For FACS starting dilution is: 1:10~50
GNE is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It is a rate-limiting enzyme in the sialic acid biosynthetic pathway. Sialic acid modification of cell surface molecules is crucial for their function in many biologic processes, including cell adhesion and signal transduction. Differential sialylation of cell surface molecules is also implicated in the tumorigenicity and metastatic behavior of malignant cells.
- Reinke, S.O., et al. Glycoconj. J. 26(4):415-422(2009)
- Tong, Y., et al. PLoS ONE(10), E7165 (2009)
- Klootwijk, R.D., et al. FASEB J. 22(11):3846-3852(2008)
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Predicted species reactivity based on immunogen sequence: Hamster, Rat
This GNE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 580-607 amino acids from the C-terminal region of human GNE.
10020
Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
GNE
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
79 kDa
Q9Y223
45476991
This antibody is purified through a protein A column, followed by peptide affinity purification.
Cell Cycle
Q9Y223
Optimal dilutions for each application to be determined by the researcher.