Further Information
Dual specificity protein phosphatase 4, Dual specificity protein phosphatase hVH2, Mitogen-activated protein kinase phosphatase 2, MAP kinase phosphatase 2, MKP-2, DUSP4, MKP2, VH2
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:50~100
DUSP4 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. DUSP4 inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus.
- Chen, P., et al., J. Biol. Chem. 276(31):29440-29449 (2001).
- Smith, A., et al., Genomics 42(3):524-527 (1997).
- Chu, Y., et al., J. Biol. Chem. 271(11):6497-6501 (1996).
- King, A.G., et al., Oncogene 11(12):2553-2563 (1995).
Supplied in PBS with 0.09% (W/V) sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
This DUSP4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 331-361 amino acids from the C-terminal region of human DUSP4.
1846
Dual specificity protein phosphatase 4
DUSP4
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
43 kDa
Q13115
2499745
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Cell Cycle,Signal Transduction
Q13115
Optimal dilutions for each application to be determined by the researcher.