ProSci

DUSP6 Antibody

Product Code:
 
PSI-59-284
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
Application:
 
Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Western blot analysis in CEM cell line lysates (35ug/lane).
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Western blot analysis in mouse stomach tissue lysates (35ug/lane).
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Western blot analysis in CEM cell line lysates (35ug/lane).
Western blot analysis in mouse stomach tissue lysates (35ug/lane).

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PSI-59-284-400ul400ul£626.00
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Further Information

Additional Names:
Dual specificity protein phosphatase 6, Dual specificity protein phosphatase PYST1, Mitogen-activated protein kinase phosphatase 3, MAP kinase phosphatase 3, MKP-3, DUSP6, MKP3, PYST1
Application Note:
For WB starting dilution is: 1:1000
Background:
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene.
Background References:
  • Chiappinelli, K.B., et al. Gynecol. Oncol. 119(1):146-150(2010)
  • Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
  • Nunes-Xavier, C.E., et al. J. Biol. Chem. 285(34):26417-26430(2010)
  • Zhang, Z., et al. Carcinogenesis 31(4):577-586(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine
Immunogen:
This DUSP6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 59-88 amino acids from the N-terminal region of human DUSP6.
NCBI Gene ID #:
1848
NCBI Official Name:
Dual specificity protein phosphatase 6
NCBI Official Symbol:
DUSP6
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
42 kDa
Protein Accession #:
Q16828
Protein GI Number:
108860971
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Neuroscience
Swissprot #:
Q16828
User NOte:
Optimal dilutions for each application to be determined by the researcher.