ProSci

SEMA4A Antibody

Product Code:
 
PSI-58-716
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
Application:
 
Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Western Blot at 1:500 dilution Lane 1: HL-60 whole cell lysate Lane 2: THP-1 whole cell lysate Lysates/proteins at 20 ug per lane.
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Western blot analysis in mouse kidney tissue lysates (35ug/lane).
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Western Blot at 1:500 dilution Lane 1: HL-60 whole cell lysate Lane 2: THP-1 whole cell lysate Lysates/proteins at 20 ug per lane.
Western blot analysis in mouse kidney tissue lysates (35ug/lane).

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PSI-58-716-400ul400ul£626.00
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This product comes from: United States.
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Further Information

Additional Names:
Semaphorin-4A, Semaphorin-B, Sema B, SEMA4A, SEMAB, SEMB
Application Note:
For WB starting dilution is: 1:500
Background:
This gene encodes a member of the semaphorin family of soluble and transmembrane proteins. Semaphorins are involved in numerous functions, including axon guidance, morphogenesis, carcinogenesis, and immunomodulation. The encoded protein is a single-pass type I membrane protein containing an immunoglobulin-like C2-type domain, a PSI domain and a sema domain. It inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons. It is an activator of T-cell-mediated immunity and suppresses vascular endothelial growth factor (VEGF)-mediated endothelial cell migration and proliferation in vitro and angiogenesis in vivo. Mutations in this gene are associated with retinal degenerative diseases including retinitis pigmentosa type 35 (RP35) and cone-rod dystrophy type 10 (CORD10). Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
Background References:
  • Davila, S., et al. Genes Immun. 11(3):232-238(2010)
  • Schmidt-Kastner, R., et al. Mol. Vis. 14, 125-135 (2008) :
  • Toyofuku, T., et al. EMBO J. 26(5):1373-1384(2007)
  • Abid, A., et al. J. Med. Genet. 43(4):378-381(2006)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This SEMA4A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 151-180 amino acids from the N-terminal region of human SEMA4A.
NCBI Gene ID #:
64218
NCBI Official Name:
Semaphorin-4A
NCBI Official Symbol:
SEMA4A
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
84 kDa
Protein Accession #:
Q9H3S1
Protein GI Number:
29840871
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Neuroscience
Swissprot #:
Q9H3S1
User NOte:
Optimal dilutions for each application to be determined by the researcher.