ProSci

Synphilin-1 Antibody

Product Code:
 
PSI-62-275
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
Application:
 
Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Western Blot at 1:1000 dilution Lane 1: human brain lysate Lane 2: U-87 MG whole cell lysate Lysates/proteins at 20 ug per lane.
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Antibody is used in Western blot to detect Synphilin-1 in mouse brain lysate.
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Western Blot at 1:1000 dilution Lane 1: human brain lysate Lane 2: U-87 MG whole cell lysate Lysates/proteins at 20 ug per lane.
Antibody is used in Western blot to detect Synphilin-1 in mouse brain lysate.

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PSI-62-275-400ul400ul£626.00
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This product comes from: United States.
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Further Information

Additional Names:
Synphilin-1, Sph1, Alpha-synuclein-interacting protein, SNCAIP
Application Note:
For WB starting dilution is: 1:1000
Background:
Parkinson is the second most common neurodegenerative disease after Alzheimers. About 1 percent of people over the age of 65 and 3 percent of people over the age of 75 are affected by the disease. The mutation is the most common cause of Parkinson disease identified to date. Synuclein alpha interacting protein (Synphilin-1) contains several protein-protein interaction domains and interacts with alpha synuclein in neurons. Mutations of SNCAIP have been linked to Parkinson disease. The amino acid sequence of synphilin-1 shows extensive homology with its human counterpart, especially in regions containing ankyrin-like motifs and the coiled-coil domain. Expression of mouse synphilin-1 in tissues is similar to its human counterpart. Synphilin-1 has an important role in the formation of aggregates and cytotoxicity in Parkinson disease and that Dorfin may be involved in the pathogenic process by ubiquitylation of synphilin-1. Role of synphilin-1 in synaptic function and protein degradation and in the molecular mechanisms leading to neurodegeneration in Parkinson disease
Background References:
  • Kruger,R. Cell Tissue Res. 318 (1), 195-199 (2004)
  • Lee,G., etal. J. Biol. Chem. 279 (8), 6834-6839 (2004)
  • Tanaka,M., et al. J. Biol. Chem. 279 (6), 4625-4631 (2004)
  • Nagano,Y., et al. J. Biol. Chem. 278 (51), 51504-51514 (2003)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This Synphilin-1 (SNCAIP) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 593-622 amino acids from the C-terminal region of human Synphilin-1 (SNCAIP).
NCBI Gene ID #:
9627
NCBI Official Name:
Synphilin-1
NCBI Official Symbol:
SNCAIP
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
100 kDa
Protein Accession #:
Q9Y6H5
Protein GI Number:
205831000
Purification:
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Research Area:
Neuroscience
Swissprot #:
Q9Y6H5
User NOte:
Optimal dilutions for each application to be determined by the researcher.