ProSci

CPE Antibody

Product Code:
 
PSI-63-109
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
Application:
 
Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Western blot analysis of CPE antibody in mouse cerebellum tissue lysates (35ug/lane)
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Western blot analysis of CPE antibody in Hela cell line lysates (35ug/lane)
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Western blot analysis of CPE antibody in mouse cerebellum tissue lysates (35ug/lane)
Western blot analysis of CPE antibody in Hela cell line lysates (35ug/lane)

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PSI-63-109-400ul400ul£626.00
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Further Information

Additional Names:
Carboxypeptidase E, CPE, Carboxypeptidase H, CPH, Enkephalin convertase, Prohormone-processing carboxypeptidase, CPE
Application Note:
For WB starting dilution is: 1:1000
Background:
CPE is a carboxypeptidase that cleaves C-terminal amino acid residues and is involved in the biosynthesis of peptide hormones and neurotransmitters, including insulin. It is a peripheral membrane protein. The protein specifically binds regulated secretory pathway proteins, including prohormones, but not constitutively secreted proteins. Mutations in CPE gene are implicated in type II diabetes.
Background References:
  • Oiso,S., J. Neurochem. 109 (1), 158-167 (2009)
  • Yang,L., Ann. N. Y. Acad. Sci. 1150, 263-266 (2008)
  • Jeffrey,K.D., Proc. Natl. Acad. Sci. U.S.A. 105 (24), 8452-8457 (2008)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine, Monkey
Immunogen:
This CPE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 381-412 amino acids from the C-terminal region of human CPE.
NCBI Gene ID #:
1363
NCBI Official Name:
Carboxypeptidase E
NCBI Official Symbol:
CPE
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
53 kDa
Protein Accession #:
P16870
Protein GI Number:
115892
Purification:
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Research Area:
Neuroscience,Signal Transduction
Swissprot #:
P16870
User NOte:
Optimal dilutions for each application to be determined by the researcher.