ProSci

PRL3 Antibody

Product Code:
 
PSI-63-469
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
Application:
 
Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Western blot analysis of PRL3 Antibody in mouse heart tissue lysates (35ug/lane)
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Western blot analysis of PRL3 Antibody in mouse heart tissue lysates (35ug/lane)

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PSI-63-469-400ul400ul£626.00
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Further Information

Additional Names:
Protein tyrosine phosphatase type IVA 3, PRL-R, Protein-tyrosine phosphatase 4a3, Protein-tyrosine phosphatase of regenerating liver 3, PRL-3, PTP4A3, PRL3
Application Note:
For WB starting dilution is: 1:1000
Background:
The protein encoded by this gene belongs to a small class of prenylated protein tyrosine phosphatases (PTPs). PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. This class of PTPs contain a PTP domain and a characteristic C-terminal prenylation motif. Studies of this class of PTPs in mice demonstrated that they were prenylated proteins in vivo, which suggested their association with cell plasma membrane. Overexpression of this gene in mammalian cells was reported to inhibit angiotensin-II induced cell calcium mobilization and promote cell growth. Two alternatively spliced variants exist. PRL-3 expression was found to be up-regulated in human liver carcinoma compared with normal liver. Its expression in colorectal cancers may contribute to the establishment of liver metastasis. In a different study, PRL-3 is found to be expressed in tumor metastasis and vasculature, regardless of the tumor source.
Background References:
  • Kato,H., et al. Clin. Cancer Res. 10 (21), 7318-7328 (2004)
  • Wu,X., et al. Am. J. Pathol. 164 (6), 2039-2054 (2004)
  • Kim,K.A., et al. FEBS Lett. 565 (1-3), 181-187 (2004)
  • Kozlov,G., et al. J. Biol. Chem. 279 (12), 11882-11889 (2004)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This PRL3 antibody is generated from rabbits immunized with a recombinant protein encoding full length of human PRL3.
NCBI Gene ID #:
11156
NCBI Official Name:
Protein tyrosine phosphatase type IVA 3
NCBI Official Symbol:
PTP4A3
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
20 kDa
Protein Accession #:
O75365
Purification:
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Research Area:
Signal Transduction
Swissprot #:
O75365
User NOte:
Optimal dilutions for each application to be determined by the researcher.