ProSci

KLHL12 Antibody

Product Code:
 
PSI-59-118
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
Application:
 
Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Western blot analysis in mouse NIH-3T3 cell line lysates (35ug/lane).
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Western blot analysis in Hela cell line lysates (35ug/lane).
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Western blot analysis in mouse NIH-3T3 cell line lysates (35ug/lane).
Western blot analysis in Hela cell line lysates (35ug/lane).

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PSI-59-118-400ul400ul£626.00
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Further Information

Additional Names:
Kelch-like protein 12, CUL3-interacting protein 1, DKIR homolog, hDKIR, KLHL12, C3IP1
Application Note:
For WB starting dilution is: 1:1000
Background:
Serves as a substrate-specific adapter for the CUL3-based ubiquitin-protein E3 ligase complex. Negatively regulates the Wnt signaling pathway via the targeted ubiquitination and subsequent proteolysis of DVL3.
Background References:
  • Ehret, G.B., et al. Eur. J. Hum. Genet. 17(12):1650-1657(2009)
  • Rondou, P., et al. J. Biol. Chem. 283(17):11083-11096(2008)
  • Lim, J., et al. Cell 125(4):801-814(2006)
  • Angers, S., et al. Nat. Cell Biol. 8(4):348-357(2006)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine, Zebrafish, Rat, Xenopus
Immunogen:
This KLHL12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 376-404 amino acids from the C-terminal region of human KLHL12.
NCBI Gene ID #:
59349
NCBI Official Name:
Kelch-like protein 12
NCBI Official Symbol:
KLHL12
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
63 kDa
Protein Accession #:
Q53G59
Protein GI Number:
97054498
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Swissprot #:
Q53G59
User NOte:
Optimal dilutions for each application to be determined by the researcher.