ProSci

IKZF3 Antibody

Product Code:
 
PSI-61-999
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit Ig
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
Application:
 
Western Blot (WB)
Storage:
 
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Western blot analysis in mouse liver tissue lysates (15ug/lane).This demonstrates the detected IKZF3 protein (arrow).
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Western blot analysis of extracts from MM cells, treated with DMSO or lenalidomide, using rabbit polyclonal IKZF3 Antibody .
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Western blot analysis in mouse liver tissue lysates (15ug/lane).This demonstrates the detected IKZF3 protein (arrow).
Western blot analysis of extracts from MM cells, treated with DMSO or lenalidomide, using rabbit polyclonal IKZF3 Antibody .

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PSI-61-999-400ul400ul£626.00
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Further Information

Additional Names:
Zinc finger protein Aiolos, Ikaros family zinc finger protein 3, IKZF3, ZNFN1A3
Application Note:
For WB starting dilution is: 1:1000
Background:
This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. At least six alternative transcripts encoding different isoforms have been described.
Background References:
  • Billot, K., et al. Leuk. Res. 34(3):289-293(2010)
  • Hirschfield, G.M., et al. N. Engl. J. Med. 360(24):2544-2555(2009)
  • Mavaddat, N., et al. Cancer Epidemiol. Biomarkers Prev. 18(1):255-259(2009)
  • Vieira, A.R., et al. Genet. Med. 10(9):668-674(2008)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine
Immunogen:
This IKZF3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 76-103 amino acids from the Central region of human IKZF3.
NCBI Gene ID #:
22806
NCBI Official Name:
Zinc finger protein Aiolos
NCBI Official Symbol:
IKZF3
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
58 kDa
Protein Accession #:
Q9UKT9
Protein GI Number:
212276437
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Swissprot #:
Q9UKT9
User NOte:
Optimal dilutions for each application to be determined by the researcher.